From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis.
نویسندگان
چکیده
1 Introduction 2 Biogenesis of plant cannabinoids 3 Metabolism 4 Synthesis 5 Molecular basis of cannabinoid action 6 Anandamide 7 2-Arachidonoylglycerol (2-Ara-Gl) 8 Structure–activity relationships of tetrahydrocannabinol (THC) derivatives and of endocannabinoids 9 Biosynthesis and inactivation of the endocannabinoids 10 Pharmacology of THC and of the endocannabinoids 11 Cannabinoids as therapeutic agents 12 Conclusions 13 References
منابع مشابه
Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms.
Anandamide is a ligand of the endocannabinoid system. Animals show a depletion following repeated Δ(9)-tetrahydrocannabinol (THC) administration but the effect of cannabis use on central nervous system levels of endocannabinoids has not been previously examined in humans. Cerebrospinal fluid (CSF) levels of the endocannabinoids anandamide, 2-arachidonoylglycerol (2-AG) and related lipids were t...
متن کاملCannabinoids in Autism and Fragile X Syndrome: Value-Based Treatment Revolution Ahead?
Cannabis has a long history in Central and South Asia, as it was used to produce hemp fibre for rope, clothing and paper, but was also consumed both for recreational and medicinal purposes. The two major neuro active components in cannabis are the psychoactive Δ9-tetrahydro-cannabinol (Δ9-THC) and the non-psychoactive cannabidiol (CBD). Recent years have seen a resurgence in interest in the the...
متن کاملThe endocannabinoid system and pain.
The therapeutic potential of cannabinoids has been the topic of extensive investigation following the discovery of cannabinoid receptors and their endogenous ligands. Cannabinoid receptors and their endogenous ligands are present at supraspinal, spinal and peripheral levels. Cannabinoids suppress behavioral responses to noxious stimulation and suppress nociceptive processing through activation ...
متن کاملAnandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand.
Two endogenous ligands for cannabinoid receptors, anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol, lose their biological activities by enzymatic hydrolysis. A cDNA for a rat liver enzyme hydrolyzing anandamide as well as oleamide was overexpressed in COS-7 cells. When the particulate fraction was allowed to react with 2-arachidonoylglycerol, arachidonic acid was produced. In con...
متن کامل[Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol].
Marijuana has been used as a traditional medicine and a pleasure-inducing drug for thousands of years around the world, especially in Asia. Delta(9)-tetrahydrocannabinol, major psychoactive component of marijuana, has been shown to interact with specific cannabinoid receptors, thereby eliciting a variety of pharmacological responses in experimental animals and human. In 1990, the gene encoding ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Natural product reports
دوره 16 2 شماره
صفحات -
تاریخ انتشار 1999